NLRP3 and obesity due to melanocortin 4 receptor deficiency: Our data show that although NLRP3 and ASC (Pycard) deficient mice gained significantly less weight after 1 year on a HFD, all three genotypes did develop obesity, which was associated with cardiac hypertrophy, with similar heart weights and cardiomyocyte cross-sectional areas in the different mouse strains.