Pro- and active- forms of IL-1β have been found to be upregulated in the vitreous humor (19, 22, 24–26, 109, 140, 145, 149), aqueous humor (21, 238), retina (209), and serum (12, 145, 239) of patients with retinal degenerations such as wet AMD (12, 19, 239), diabetic macular edema (149, 238), retinal detachment (109, 208, 209), RVO (19, 201), glaucoma (21), retinitis pigmentosa (22), and diabetic retinopathy (19, 24–26, 140, 144, 145, 240). The gene discussed is IL1B; the disease is glaucoma.