However, independent studies into IL-1 gene cluster polymorphisms such as C/T polymorphism in the promoter region of IL-1α, IL-1α (−889) T allele, and two C/T polymorphisms in IL-1β, rs16944 (−511 C/T) and rs1143634 (+3953C/T), have reported conflicting information on POAG and normal-tension glaucoma (NTG) disease susceptibility (179–185), promoting a meta-analysis to investigate the relationship between these polymorphisms and glaucoma risk factor. The gene discussed is IL1B; the disease is glaucoma.