CXCL1 and retinal degeneration: It was demonstrated that inhibition of IL-1β using both small interfering RNA (siRNA) and a neutralizing antibody was able to ameliorate retinal degeneration, reducing immune cell recruitment to the outer retina, and production of chemokines (Ccl2, Cxcl1, Cxcl10) from both Müller glia and RPE cells, ultimately slowing photoreceptor cell death in retinal degeneration (18).