In a retrospective case-controlled study of polymorphisms in interleukin genes of nearly 500 late-stage Taiwanese dry AMD patients and controls, no single nucleotide polymorphisms (SNPs) in the IL-1β gene were found associated with the development of AMD (110), indicating little association exists between dysfunctional IL-1β gene expression and dry AMD. The gene discussed is IL1B; the disease is dry age related macular degeneration.