Pro- and active- forms of IL-1β have been found to be upregulated in the vitreous humor (19, 22, 24–26, 109, 140, 145, 149), aqueous humor (21, 238), retina (209), and serum (12, 145, 239) of patients with retinal degenerations such as wet AMD (12, 19, 239), diabetic macular edema (149, 238), retinal detachment (109, 208, 209), RVO (19, 201), glaucoma (21), retinitis pigmentosa (22), and diabetic retinopathy (19, 24–26, 140, 144, 145, 240). Here, IL1B is linked to wet macular degeneration.