IL1B and early-onset autosomal dominant Alzheimer disease: An increase in IL-1β was found in the vitreous of rats injected intravitreally with drusen component amyloid beta (Aβ) (111, 112), a toxic peptide aggregate known to accumulate in neurodegenerative diseases such as Alzheimer's disease [reviewed in Murphy and LeVine (113)], as well as in dry AMD (114, 115).