In support of “memory-like” CD8+ T cell development during this infection is the finding that virus-specific T cells transferred into naïve mice 4 weeks after initial infection with LCMV Cl13 were able to expand and control viral titers when recipient mice were infected with the acute virus LCMV Armstrong strain, despite retaining high PD-1 expression levels and reduced (but not absent) IFN-γ and TNF-α production (93). This evidence concerns the gene IFNG and infection.