RIGI and viral infectious disease: Nevertheless, some viral infections can potentially expose these endogenous circRNAs for immune detection, as has recently been found to be the case for a novel host-derived circRNA (lnc-Lsm3b) that is IFN-inducible and shows a down-regulation of its binding to host proteins during viral infection and therefore appears to compete with viral dsRNA as an inhibitor of the RIG-I signaling feedback loop (198).