IL10 and lung carcinoma: Consistent with animal studies and human clinical trial data showing that IL-10 promotes CD8+ TIL proliferation (11, 17, 18, 61), addition of IL-10 to in vitro culture of TILs from human lung cancer with IL-2 drastically enhances the quantity and quality of the expanded human TILs and upregulates genes related to several signaling pathways, such TCR signaling, Notch signaling, cell cycle and CTL killing (11).