In hepatocellular carcinoma (HCC) cell lines, miR-505 negatively regulates HMGB1, increasing doxorubicin cytotoxicity in vitro via enhanced caspase 3 activity, induction of DNA damage and decreased phosphorylation of Akt, a pathway known to be closely involved in drug resistance (191). This evidence concerns the gene CASP3 and hepatocellular carcinoma.