Dendritic cells (DCs) preferentially present antigens from NETotic neutrophils (60) and HMGB1 present in NETs released by neutrophils from pedriatic SLE patients up-regulate type I interferon production by tissue plasmacytoid DCs, which further stimulates the release of NETs and aggravates the disease (61). This evidence concerns the gene HMGB1 and systemic lupus erythematosus.