HMGB1 and neoplasm: TIM-1+ Breg are excellent producers of IL-10, presenting a correlation with increased recurrence, decrease of overall survival and disease-free survival of hepatocellular carcinoma patients (143), which together are associated with a poor prognosis.On the other hand, treatment of cervical cancer cell lines with 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) can increase HMGB1 content in tumor-derived Exo, which was found to be beneficial to the activation of APCs, inducing secretion of IL-6, IL-12, IL-18, IFN-γ, and TNF-α in vitro (144).