Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by high levels of serum IgE and pruritic skin lesions that are infiltrated by mast cells, eosinophils, macrophages, DCs and T cells, particularly those of the Th2 profile, with cytokines like IL-4, IL-13, and IL-31 playing important roles in its pathophysiology (86). Here, IL4 is linked to Alzheimer disease.