HMGB1 and neoplasm: Less differentiated carcinoma presented more diffused localization of HMGB1 in the nucleus (155);Cytoplasmic HMGB1 associated with small tumor size and early stages (151); no prognostic significance (152); cytoplasmic HMGB1 associated with TIL, but no prognostic significance (153) (156);post-chemotherapy increase in circulating HMGB1 correlated with better survival (154)