HMGB1 and neoplasm: While HMGB1 plays a role in sustaining chronic inflammation and promoting wound healing, it can also trigger pathways which promote tumor growth including angiogenesis, reparative epithelial proliferation, efferocytosis by recruited macrophages and inhibition of immune effectors mediated by myeloid derived suppressor cells (MDSCs) and T regulatory cells (Tregs) (116).