To explore the role of HSP90α/β and β as potential biomarkers in adrenal tumors, their expression was evaluated by immunohistochemistry in FFPE samples from patient group 1, which included 32 patients with non-functional adenomas (NFA), adenomas associated with autonomous cortisol secretion (ACS) and overt Cushing's syndrome (CS) and ACC, respectively (Supplemental Table 1A). This evidence concerns the gene HSP90AA1 and adenoma.