NR1I3 and metabolic dysfunction-associated steatohepatitis: Kettner et al. demonstrated that chronic circadian disruption induces NAFLD and spontaneous hepatocarcinogenesis, promotes genome-wide deregulation and metabolic disruption, and activates CAR (NR1I3, constitutive androstane receptor) which drives NAFLD to NASH, fibrosis and HCC progression (78).