FXR was significantly increased in pancreatic cancer cell lines in comparison to normal pancreatic cells and FXR was found as the regulator of FAK (PTK2, protein tyrosine kinase 2)/c-Jun (JUN, Jun proto-oncogene, AP-1 transcription factor subunit) / MUC4 (mucin 4) signaling pathway (124). Here, NR1H4 is linked to familial pancreatic carcinoma.