UCP1 and hydrops fetalis: As shown in Figure 2, the mRNA expression of browning markers was significantly decreased in mice fed a HF diet compared to that fed a control diet, including Ucp1 (p < 0.05), Cidea (p < 0.001), PGC1α (p < 0.01), PPARα (p < 0.01), and PPARγ (p < 0.05).