Dhanesha et al generated platelet-derived VWF (Plt-VWF) mice, Plt-VWF mice with ADAMTS13 deficiency, and endothelial cell-derived VWF (EC-VWF/ADAMTS13−/−) mice through bone marrow transplantation to determine the function of different types of VWF in stroke. Here, VWF is linked to Stroke.