RANBP17 is upregulated in dilated cardiomyopathy and ischemic cardiomyopathy samples, and may regulate the transport of different cargos in specific cardiomyopathies through enhancing the transcriptional activation of the EA2 transcription factors E12 and E47 (39). The gene discussed is CACNA1A; the disease is ischemic cardiomyopathy.