PTGS2 and lung carcinoma: Moreover, miR-146a is also known to regulate COX-2 expression in lung cancer (Cornett and Lutz, 2014), which indicates a role of miR-146a as an endogenous dual inhibitor of AA metabolism in lung cancer by regulating prostaglandins and LTs, similar to miR-216a-3p (Iacona et al., 2018).