In the present study, we used the established AD in vitro model in APPswe cells and found through apoptotic and cytoactive analyses that Aβ led to high apoptotic ratios of neurons, accompanied by the activation of the Bax/caspase-3 axis, whereas upregulation of miR-200a-3p rescued neural apoptosis and recovered the apoptotic caspase-3 pathway. This evidence concerns the gene BAX and Alzheimer disease.