The phosphorylation of tau at serine 396 and 404 sites was observed in early and late stages of AD and has been demonstrated to have greater preference in the earliest formation of NFTs, whereas the serine 214, serine 202, threonine 205 sites have been shown to be mostly associated with mature NFTs (Mondragon-Rodriguez et al., 2014). The gene discussed is MAPT; the disease is Alzheimer disease.