Moreover, uncoupling of GluN2B C-terminal-dependent signaling or selective GluN2B blockade has antidepressant effects (Li et al., 2018) and might exert neuroprotective properties in Alzheimer’s disease, Huntington’s disease, and after stroke (Dau et al., 2014; Wu and Tymianski, 2018; Xu et al., 2019). The gene discussed is GRIN2B; the disease is early-onset autosomal dominant Alzheimer disease.