FAAH and Cognitive impairment: In contrast, when AEA levels are increased via the pharmacological inhibition of the FAAH or by genetic FAAH deletion, cognitive abilities are improved (Piomelli et al., 2006; Varvel et al., 2007; Panlilio et al., 2013) even if studies reporting cognitive impairments after FAAH inhibition are also evident (Busquets-Garcia et al., 2011; Goonawardena et al., 2011).