Thus, in light of our new data, it might be tempting to speculate that the FAAH inhibition per se as well as FAAH inhibition with concomitant blockade of AEA uptake and/or TRPV1 channels might be a more efficient approach to improve cognitive dysfunctions in ADHD (Tzavara et al., 2006), with reduced side effects compared to those of cannabis or ∆9-THC. The gene discussed is TRPV1; the disease is attention deficit-hyperactivity disorder.