Tumor growth-inhibition of 5.8% treated with 50 mg/kg and 50.3% treated with 100 mg/kg of graviola extract The extract reducedpancreatic cells viability through increment of intracellular ROS and necrosis cell death, and cell cycle arrest Diminished MMP3 levels in tumors reducing metastasis and invasion. Here, MMP3 is linked to neoplasm.