In addition, licochalcone A and licoisoflavanone acted on the proteins 5-hydroxytryptamine 1A receptor (HTR1A), ADRB1, cell division protein kinase 5 (CDK5), D opioid receptor (OPRD1), GSK3B, and HRH1; therefore, they may exert synergetic effects to achieve anti-ischemic effects to treat ischemic heart disease (Liu et al., 2013a). Here, CDK5 is linked to coronary artery disorder.