EGFR and Cognitive impairment: Among these pathways, the gene category “IL-17 signaling pathway” has been reported to play a pivotal role in cognitive impairment (Tian et al., 2015); the gene category “ErbB signaling pathway” has been found to be implicated in inhibition of long-term potentiation (LTP) in hippocampus (Pitcher et al., 2008).