Intracellular Aβ accumulation can markedly affect glutamatergic synaptic transmission and plasticity (Ripoli et al., 2014), cognitive impairment (Iulita et al., 2014), neuronal death (Umeda et al., 2011), inflammatory signs and tau phosphorylation (Rebeck et al., 2010), and mitochondrial dysfunction (Zepa et al., 2011). This evidence concerns the gene MAPT and Cognitive impairment.