ITIH4 and peripheral neuropathy: HIV gp120 transgenic mice or rodents treated with gp120 develop neuropathic pain with pathological similarities with humans such as peripheral neuropathy, pain behavior, synaptic degeneration and activation of glial cells (Nagano et al., 1996; Oh et al., 2001; Wallace et al., 2007; Hao, 2013; Burdo and Miller, 2014).