Dysregulated calcineurin-NFAT signaling might be implicated in the dysregulation of TMP21 in AD as TMP21 is positively regulated by NFAT at transcriptional level (Abdul et al., 2009; Liu et al., 2011; Sun et al., 2014; Wu et al., 2014a). Here, TMED10 is linked to Alzheimer disease.