TMED10 and Alzheimer disease: Moreover, a number of putative cis-acting elements located in TMP21 promoter region might be implicated in the dysregulation of TMP21 transcription as various transcriptional factors are altered in AD, such as CREB (Liu et al., 2011; Pugazhenthi et al., 2011; Bartolotti et al., 2016; Ettcheto et al., 2018).