For example, miRNA-195 prevents dendritic degeneration and neuron death in CCH rats (Chen et al., 2017); the TNFα–miR-501-3p–ZO-1 axis plays an important role in the pathogenesis of CCH induced memory deficits and WMD (Toyama et al., 2018). Here, TNF is linked to columnar cell hyperplasia of the breast.