In AD patients and preclinical AD models, a high expression of α7 nAChR was described (Hellström-Lindahl et al., 1999, 2004a,b; Dineley et al., 2002; Jones et al., 2006; Counts et al., 2007; Ikonomovic et al., 2009). The gene discussed is CHRNA7; the disease is Alzheimer disease.