Cc2d1a is highly expressed in neurons and has been implicated in intellectual disability and autism spectrum disorder (Basel-Vanagaite et al., 2006; Manzini et al., 2014), Cc2d1b is expressed in myelinating glial cells and peripheral nerves4,5 (Zhang et al., 2014), which indicates that its role and function might not be fully redundant with Cc2d1a. This evidence concerns the gene CC2D1B and Intellectual disability.