PGP and epilepsy: After their discovery in chemotherapeutic resistant cancer (Juliano and Ling, 1976), P-gp was the first ABC-transporter described to be related with drug-resistant epilepsy as well as in brain and heart hypoxia-ischemia (Tishler et al., 1995; Lazarowski et al., 1999, 2004, 2005, 2007; Ramos et al., 2004).