Furthermore, in AD group, rs9357347 was found to exert a strong effect on CSF T-tau (β = -0.47, P = 0.002) (Figure 1F) and P-tau 181 (β = -0.33, P = 0.019) (Figure 1G), while we failed to discover similar correlation in MCI and CN groups. The gene discussed is MAPT; the disease is Alzheimer disease.