Specifically, we reported that rs9357347 was mainly associated with CSF Aβ1-42 in CN participants; in AD participants, the mutation was detected to be negatively associated with CSF T-tau, which is consistent with the result in Aβ+ group; the association between the locus and CSF P-tau 181 was also found in AD group longitudinally. The gene discussed is MAPT; the disease is Alzheimer disease.