Sig-1R ligands modulate cellular functions, such as ion channel activity, neuronal firing, neuronal differentiation, cancer growth, and cell death/apoptosis, as well as behaviors related to neurological and neuropsychiatric disorders such as substance addiction (e.g., cocaine and methamphetamine abuse), depression, schizophrenia, amyotrophic lateral sclerosis, and Alzheimer’s disease (Mavlyutov et al., 2010, 2013; Su et al., 2010; Maurice and Goguadze, 2017; Nguyen et al., 2017). The gene discussed is SIGMAR1; the disease is cancer.