SH2B1 and obesity disorder: Maillard et al. (2015) also showed that the 16p11.2 locus regulated brain structures common to autism and obesity. Criado et al. (2017) indicated that identification of factors of obesity risk in children with ASD served as a prerequisite for addressing long-term individual health burdens and societal costs in this population. The data reported here suggested that epigenetic changes of SH2B1 might confer risk of ASD.