S100A8 and holoprosencephaly: The median serum CagA antibody titers (GC group/non-GC group) were 6.35/9.88 U/ml before HPE (p = 0.43), 3.23/1.21 U/ml at 0.5–2 years after HPE (p = 0.49), 0.42/0.83 U/ml at 2–5 years after HPE (p = 0.20), and 0.72/0.66 U/ml at 5–7 years after HPE (p = 0.34; Fig. 2).