Recently, serum acylated ghrelin levels have been reported to be associated with gastric emptying, anxiety,(16) depressive status(17) and intestinal metaplasia.(18) In this study, we have first investigated whether serum acylated ghrelin levels were associated with anxiety, clinical symptoms, depressive status, quality of life, gastric motility and endoscopic findings based on Kyoto classification in FD patients. This evidence concerns the gene GHRL and Anxiety.