Other biomarkers have also been evaluated and used for the prediction of diabetes, including adiponectin,(5) leptin,(13,14) glycoalbumin,(15) and retinol binding protein 4 (RBP4).(16,17) Fat accumulation in the human body releases several adipokines from adipocytes, and some of these adipokines are known to aggravate insulin resistance, cause metabolic syndrome, and promote T2D. The gene discussed is LEP; the disease is diabetes mellitus.