TNF and osteoporosis: In contrast to anti‐TNFα monoclonal antibody, anti‐inflammatory glucocorticoids downregulate several proinflammatory genes.126, 127, 128, 146 Still, the anti‐inflammatory glucocorticoid function is counteracted by proinflammatory cytokines, TNFα and IL‐1β.147 Moreover, the metabolic side effects of glucocorticosteroids such as hyperglycaemia, hyperlipidemia and osteoporosis are of concern.146, 148, 149 These limitations and other drawbacks of current anti‐inflammatory agents inspired us to search for alternative, wide‐reaching, anti‐inflammatory measures.