SOCS3 and inflammatory response: By bioengineering recombinant cell‐penetrating SOCS1 and SOCS3, we introduced a new class of anti‐inflammatory intracellular protein therapy.21, 154, 155 Within minutes, CP‐SOCS3 replenished the intracellular stores of SOCS3 that would be consumed during acute liver inflammation (see Figure 3).