Overnutrition with saturated fatty acid palmitate activates hepatocellular NF‐κB through BCL10, which is driven by the diacyl glycerol‐protein kinase C pathway.266 We posit that the activation of NF‐κB signalling pathway represents a “tipping point” in the transition of liver steatosis to steatohepatitis. This evidence concerns the gene NFKB1 and overnutrition.