Its target, the JAKs, display an intrinsically complex structure comprising the 4.1, ezrin, radixin, moesin SH2 (Src homology 2) pseudokinase and kinase domains.164 The short 16‐amino acid peptide mimetics of SOCS1 KIR domain were designed with an attached lipophilic group to penetrate the cell membrane and target JAKs.165 In a murine model of experimental allergic encephalomyelitis, SOCS1‐KIR peptide alleviated paraplegia and other signs of the cellular infiltration of the central nervous system. This evidence concerns the gene SOCS1 and paraplegia.