The intracellular delivery of recombinant cell‐penetrating (CP)‐CRADD restored endothelial barrier function and suppressed the production of inflammatory mediators IL‐6 and monocyte chemoattractant protein‐1.137 CRADD's target, Bcl10, is essential for the development of atherosclerosis and abdominal aortic aneurysms, the bulging weak spots in the vascular wall that can dissect and rupture in ApoE‐deficient mice. The gene discussed is APOE; the disease is atherosclerosis.