IKBKB and rheumatoid arthritis: IKKβ is targeted selectively by a cell‐penetrating peptide delivering the NEMO‐binding domain to disrupt the NF‐ĸB signalling pathway.198, 199 A modified version of this peptide termed the “sneaking ligand construct” was designed to target IKKβ in endothelial cells to ameliorate rheumatoid arthritis in experimental model.200