Suppression of glucose production from hepatic cells and restoration of glycemic control in T2D mice suggested that glucose-6-phosphatase, which catalyzes the terminal step in gluconeogenesis and glycogenolysis and whose expression is inhibited by post-prandial insulin in normal liver cells [1, 28], may also be downregulated by the action of NPC43. This evidence concerns the gene INS and type 2 diabetes mellitus.