Figure 4b displays the expression status of four differentially expressed PI3K/AKT-related genes (PDGFB and CCND1 regulated by c-Jun in PTENWT, CDK6, and BCL2 regulated by c-Jun in PTENHemDel), the associated c-Jun peaks (red arrows; ChIP-Seq) and the H3K27 acetylation status around the c-Jun peaks (blue), illustrating the differences in transcriptionally active genomic regions between NHEMs and melanoma cell lines. The gene discussed is CCND1; the disease is melanoma.