Further, we investigated overall survival of 471 skin cutaneous melanoma patients based on the PTEN and c-Jun expression status, and could clearly show that melanoma patients with alterations in both, c-Jun and PTEN, belong to the high risk group, whereas patients with either PTENWT or c-JunWT belong to the low risk group (Fig. 6b, c). Here, JUN is linked to cutaneous melanoma.