In summary, numerous differentially expressed genes in PTENWT and PTENHemDel cells belonging to the PI3K/AKT-signaling pathway are regulated by c-Jun (Supplementary Fig. 5, STRING; red: members of PI3K-signaling system), indicating again that c-Jun plays a crucial role in early melanoma development to promote survival in the presence of PTEN. Here, PTEN is linked to melanoma.