Several of the proteins that we found to be differentially expressed/abundant in Fabry CMs or in the extracellular space have known roles in other LSDs (including Gaucher disease, SCARB2/LIMP-2 and GBA; Krabbe disease, GALC; and ceroid lipofuscinosis, CTSF), but had never been implicated in FD. This evidence concerns the gene GALC and Fabry disease.