After multivariable analysis, including significant variables in the previous analysisplus age at the diagnosis of SLE and ethnicity, only age at diagnosis of SLE (OR 1.04,P =0.014; 95% CI 1.00, 1.08), taking azathioprine ever (OR 5.26,P =0.006; 95% CI 1.62, 17.1) kidney disease (OR 4.22;P =0.006; 95% CI 1.51, 11.76), CNS manifestations (OR 3.56,P =0.007; 95% CI 1.42, 8.95) and positive anti-RNP antibody (OR 3.45P =0.029; 95% CI 1.22, 9.8) remained statistically significant. This evidence concerns the gene RNPC3 and kidney disorder.