In one study, Yu et al. (35)showed down-regulation of miR-30 family, exclusivelymiR-30e, interferes with tumor beginning BCSCs (inmammospheres as well as primary BCSCs acquired frombreast cancer patients) through up-regulation of ubiquitinconjugatingenzyme 9 (Ubc9) and integrin b3 (ITGB3).This up-regulation results in reduced self-renewal andanti-apoptotic features of BCSCs. This evidence concerns the gene UBE2I and cancer.