CCND1 and lung large cell carcinoma: HMGA1was found to play a critical role in transformation throughup-regulating MMP-2 in large-cell lung carcinoma (32).BTG2 overexpression may inhibit MMP-1, MMP-2 andcyclin D1 (CCND1) expression in lung cancer A549cell line, and it also has potential of suppressing tumorcell proliferation, growth and invasiveness (33, 34).