Besides, several miRNAs (includinghsa-miR-16-5p, hsa-let-7b-5p, hsa-miR-15a-5p, hsa-miR15b-5p, hsa-let-7a-5p and hsa-miR-34a-5p) and genes(including HMGA1, BTG2, SOD2, FOS and TP53) mightassociate with the pathogenesis of NSCLC and they mightbe applied for targeted therapy of NSCLC. This evidence concerns the gene HMGA1 and non-small cell lung carcinoma.