HMGA1was found to play a critical role in transformation throughup-regulating MMP-2 in large-cell lung carcinoma (32).BTG2 overexpression may inhibit MMP-1, MMP-2 andcyclin D1 (CCND1) expression in lung cancer A549cell line, and it also has potential of suppressing tumorcell proliferation, growth and invasiveness (33, 34). Here, MMP2 is linked to lung large cell carcinoma.