Similarly, we showed that overexpressionof miR-302/367 cluster in MDA-MB-231 and SKBR-3 cells induces expression of OCT4 gene (18) anddownregulates expression of AKT1. Therefore, it seemsthat a mechanism, similar to that of previous reports, isapplicable to breast cancer cells. The gene discussed is POU5F1; the disease is breast cancer.