In this study, we investigated how overexpressionof miR-302/367 cluster in MDA-MB-231 and SKBR-3 breast cancer cells affects some mediators ofTGF-β/MAPK/AKT signaling pathway at gene level.As shown, TGFBR2 and RHOC are directly targetedby miR-302 cluster, subsequently facilitating human ormouse fibroblast reprogramming towards iPS cells (27,28). The gene discussed is RHOC; the disease is breast cancer.