Thus, ß-elemene causes radiosensitization via areduction in the repair of double strand break (DSB)or an increase in radiation-induced DNA damage (17).Furthermore, recent studies have shown that radiationcan increase the mRNA/protein expression of survivinin tumor cells and also increase HIF-1a activity.It hasbeen observed that tumors highly expressing survivinor HIF-1a are resistant to radiation. The gene discussed is HIF1A; the disease is neoplasm.