In this work, we demonstrated that using peptidetherapy and natural products together can producesynergistic effects on differentiation of MSCs into IPCs.In recent years, GLP-1, a peptide produced by dipeptidylpeptidase-4 (DPP4) cleavage of the gut incretin hormone,has attracted tremendous attention from scientificcommunity for T1DM therapy because it can act as agrowth factor to increase mass expansion of ß-cells andsubsequently, insulin secretion. This evidence concerns the gene DPP4 and type 1 diabetes mellitus.