AKT1 and cancer: 16 demonstrated that exogenous H2S can prevent cytotoxicity, apoptosis and excessive production of reactive oxygen species, as well as decrease superoxide dismutase activity and metalloproteinase dissipation, by activating the HSP90/Akt pathway, so as to protect H9c2 myocardial cells from mercury‐induced damage. In addition, some studies have shown that some HSP90 inhibitors can induce autophagy via inactivation of the Akt/mTOR pathway 30, 31, 32, 33. Another study has also indicated that the Akt/mTOR pathway is involved in regulating the proliferation and apoptosis of cancer cells 17.