ACTB and Cognitive impairment: Moreover, a single-nucleotide polymorphism (SNP) of the ACTB gene that caused missense mutations was shown to be linked with several neurological phenotypes, including global developmental delay, intellectual disability, cognitive impairment, abnormal aggressive and impulsive behavior, attention deficit, hyperactivity, and autism spectrum disorders (based on DECIPHER database; http://www.decipher.sanger.ac.uk/, accessed 2018).