CD8A and neoplasm: In multivariate Cox regression analysis, attenuated NOVA1 expression in tumor cells was identified as an independent poor prognostic factor for OS (Hazard ratio = 2.104, p = 0.005) and PFS (Hazard ratio = 1.599, p = 0.03), as were other clinicopathologic factors, such as older age, non-oropharynx site, advanced pathologic T stage (pT stage 3–4), advanced pathologic N stage (pN stage 2–3), and lower cell density of tumor infiltrating CD8 + cytotoxic T cells (Supplementary Tables S5 and S6).