While none of the laboratory mouse TRIM5-like proteins were previously shown to inhibit infection by any of the exogenous retroviruses tested, one previous study demonstrated that replacing the SPRY domain of mouse TRIM5 paralogs with a primate CypA led to the recognition and inhibition of the incoming HIV-1 by Trim12 but not by Trim30 variants40. The gene discussed is PPIA; the disease is infection.