Of our VP population, 85% were PR/CR responders (Fig. 3b, right), compared to clinical results showing 79% having robust responses, and with further analysis we indicate that the number of T cell clones and an increase in maximum effector T cell density in the tumor to be the main significant driving factors for response in our virtual population; similar to anti-PD-1 monotherapy case, except starting tumor diameter and %PD-L1 at therapy were less significant and the density of effector T cells in the tumor showed a wider range for responders. Here, PDCD1 is linked to neoplasm.