CD274 and cancer: Here, we aim to link how the mentioned physiological parameters that we described biologically (i.e., numbers of T cells clones, tumor size, average antigen strength, expression of PD-L1 on cancer cells, as well as the levels of inhibitory cells in the tumor and lymph node) when put into a well-mixed mechanistic framework and their values varied across defined ranges, can allow us to simulate a variety of anti-tumor responses when the dose level and regimen of each therapy is kept constant.