Further characterization of the role of Gal3 in neurodegenerative diseases is a timely issue because it has been documented that aggregations of several disease-causing proteins (such as α-synuclein, Tau, and Huntingtin) trigger rupture of intracellular vesicles, which are marked by the appearance of Gal3 puncta, in cell models of degenerative diseases22. This evidence concerns the gene MAPT and neurodegenerative disease.