Most importantly, the levels of plasma Gal3 correlated well with disease burden (Fig. 1b), Mini-Mental Status Examination (MMSE) scores (Fig. 1c), and Unified Huntington’s disease Rating Scale (UHDRS) scores (UHDRS-Motor, Fig. 1d; UHDRS-Independence, Fig. 1e; UHDRS-Functional Capacity, Fig. 1f). This evidence concerns the gene LGALS3 and Huntington disease.