Treatment of primary microglia with two different NFκB inhibitors, BAY11-702 (designated Bay11, 3 μM) or Ro 106-9920 (designated Ro106, 1 μM, Supplementary Fig. 4) for 24 h suppressed the activation of NFκB-p65 in nuclei and reduced the expression of Gal3 in HD microglia (Fig. 3a, b). This evidence concerns the gene LGALS3 and Huntington disease.