LGALS3 and neurodegenerative disease: Further characterization of the role of Gal3 in neurodegenerative diseases is a timely issue because it has been documented that aggregations of several disease-causing proteins (such as α-synuclein, Tau, and Huntingtin) trigger rupture of intracellular vesicles, which are marked by the appearance of Gal3 puncta, in cell models of degenerative diseases22.