DNMT3A and small cell lung carcinoma: Finally, both pharmacological inhibition of DNA methylation by 5-azacytidine in GLC1 cells as well as small interfering RNA (siRNA)-mediated DNMT3a knockdown in two MYC-amplified SCLC cell lines led to de-repression of BCL2 (Fig. 2j, k and Supplementary Fig. 2l).