RB1 and small cell lung carcinoma: In addition, we observed a modest trend toward a negative correlation of MYC and BCL2 in an independent cohort of SCLC patients15 (Supplementary Fig. 1i) and significantly decreased Bcl2 expression in Myc-high tumors of Myc-driven SCLC mice (RPM) compared to Trp53/Rb1-deficient SCLC mouse tumors with low Myc expression (Supplementary Fig. 1j)6.