LMNA and lipodystrophy: The phenotype of nuclear envelope-linked lipodystrophies ranges from the typical Familial Partial Lipodystrophy of the Dunnigan type (also called type 2 Familial Partial Lipodystrophy, FPLD2) due to heterozygous mutations of the LMNA gene encoding lamin A/C to complex diseases that can combine lipodystrophy, metabolic complications, bone resorption with osteoporosis and osteolysis, and signs of accelerated aging3,5,6.