VEGFA and Kaposi's sarcoma: mTORC1 substrate proteins are phosphorylated in KS lesions, and treatment of iatrogenic KS with the allosteric mTORC1 inhibitor rapamycin caused regression of KS tumors (16), likely due to diminished production of the key host angiogenic growth factor vascular endothelial growth factor A (VEGF-A) (17, 21).